Use Of Medicines For Epilepsy During Pregnancy Can Cause A Risk To The Child

Use Of Medicines For Epilepsy During Pregnancy Can Cause A Risk To The Child.


Pregnant women with epilepsy who are engaging carbamazepine (Tegretol) to lead seizures may be at a to a certain increased chance of having an infant with spina bifida, a brand-new read finds. Spina bifida is a working order in which the bones of the ray do not close but the spinal rope remains in place, usually with rind covering the defect where to purchase testosteron cream for woman, in. Most children will paucity lifelong treatment for problems arising from mar to the spinal cord and spinal nerves.



And "For women with epilepsy, annexation control during pregnancy is very important," said precede researcher Lolkje de Jong-van den Berg, from the conflict of dispensary at the University of Groningen in the Netherlands. "Our review can help in decisions regarding whether carbamazepine should be the narcotize of choice in pregnancy" tantra dubai. However, the best chance regarding treatment can be chosen only on an individual base by the woman and her neurologist before pregnancy, weighing the benefits of epilepsy conduct against the risk of birth defects, de Jong-van den Berg said.



The sign in is published in the Dec 3, 2010 online copy of the BMJ. For the study, de Jong-van den Berg's group reviewed existing investigation to draw the jeopardy of birth defects among women winsome Tegretol. The researchers found that infants of women enchanting Tegretol were 2,6 times more in all probability to have spina bifida, compared with women not alluring any anti-epileptic medication.



However, the risk associated with Tegretol was less than with another anti-epileptic drug- valproic acid (Depakene). In fact, Tegretol was less dodgy than valproic acid when it came to other delivery defects such as hypospadias, where a boy's urinary slit develops in the also off the target her of the penis or in the scrotum. "Carbamazepine is specifically tied up to an increased risk of spina bifida," de Jong-van den Berg said. "But you have to preserve in be offended by that the absolute risk is small".



For Tegretol charmed in the first trimester, the overall danger of a major malformation was 3,3 percent, the observe authors reported. The same group of researchers found in another study, published this year in the New England Journal of Medicine, that women entrancing valproic acid were six times more probably to have an infant with spina bifida and seven times more qualified have an infant with hypospadias, compared with women using other anti-epileptic drugs.



The researchers consent with a direction from the American Academy of Neurology that valproic acid should be avoided in pregnancy if possible. Dr Orrin Devinsky, boss of the Epilepsy Center at NYU Langone Medical Center, said that "for women of childbearing age, these drugs outline a risk".



Women needfulness to level the gamble and sake of these drugs, he explained. Women with epilepsy poverty to linger on an anti-epileptic antidepressant while they are pregnant, Devinsky said. "The imperil of seizure to themselves and potentially to their fetus is greater than the peril of anti-epileptic drugs," he added.



There are selection drugs, specifically lamotrigine (Lamictal) and levetiracetam (Keppra). However, there is no figures on any dangers associated with these drugs during pregnancy, Devinsky noted. Another expert, Dr Kimford Meador, a professor of neurology at Emory University School of Medicine, said women basic to be sure the risks associated with Tegretol apotik century vimax. "If a dame is of childbearing concealed and you are prescribing this drug, that's when the discussion needs to occur," Meador said.