Use Of Cholesterol Drugs By Patients Without High Cholesterol Level

Use Of Cholesterol Drugs By Patients Without High Cholesterol Level.


When the US Food and Drug Administration in February 2010 approved the use of the cholesterol-lowering statin dose Crestor for some nation with natural cholesterol levels, cardiologist Dr Steven E Nissen cheered the decision. "You have to go with the regulated evidence," said Nissen, who is chairman of cardiovascular pharmaceutical at the Cleveland Clinic Hairfinity challenge. "A clinical bother was done and there was a consequential reduction in morbidity and mortality in men and women treated with this drug".



But Dr Mark A Hlatky, a professor of condition fact-finding and practice and cure-all at Stanford University, has expressed doubts about the FDA move. He worries that more subjects will rely on a remedy rather than assembly and practise to cut their heart risk, and also points to studies linking statins such as Crestor to muscle troubles and even diabetes prezzo di acer riconia tab a500 in italia. "I haven't seen anything that changes my temper about that," Hlatky said.



So, will millions of bracing Americans soon verge on the millions of less-than-healthy folk who already document these blockbuster drugs? The FDA's Feb 9 confirmation of expanded use of rosuvastatin (Crestor) was based on results of the JUPITER study, which tortuous more than 18000 consumers and was financed by the drug's maker, AstraZeneca. People in the try-out who took the sedative for an average of 1,9 years had a 44 percent lessen endanger of heart attack, stroke and other cardiovascular problems compared to those who took a placebo - results so smashing that the provisional was cut short. Based on JUPITER, an FDA hortatory committee voted 12 to 4 in December to confirm widened use of the drug.



The commonality in the trial included men over 50 and women over 60 with run-of-the-mill or near-normal cholesterol levels. However, these individuals did have dear levels of C-reactive protein, a marker of irritation that has also been linked to cardiovascular problems. They also had at least one other nitty-gritty jeopardy factor, such as obesity or elevated blood pressure.



For that specific group, Crestor makes sense, Nissen said. "Over a five-year span of time, you stop one passing or minor stroke for every 25 people treated," he noted. Whether or not others with general cholesterol should lift Crestor or another statin remains unclear. "Not one and all with normal cholesterol should be treated," Nissen said. "You should give it to clan with a inebriated enough risk".